Our laboratory research interests primarily include studies of protein structure/function relationships, particularly involving proteolytic enzymes substrate and inhibitor interactions and specificity.

We express, purify, and characterize various proteolytic enzymes, especially aspartic proteinases such as HIV and HTLV proteases (viral), malarial proteases - plasmepsins (parasitic protozoan), and cathepsin D (mammalian). We also work to describe substrate specificity and to solve 3D structure of several plant metalloproteases: leucyl aminopeptidase 1 and aspartyl aminopeptidase 1 and 2 from Arabidopsis thaliana.